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Avoid or Use Alternate Drug. Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Use Caution/Monitor. Copyright 2014 - 2023 The Calculator .CO |All Rights Reserved|Terms and Conditions of Use, Intravenous iron-dextran: therapeutic and experimental possibilities, Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations, Treatment of iron deficiency anemia associated with gastrointestinal tract diseases, Diagnosis and management of iron deficiency anaemia: a clinical update. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. Anemia of chronic disease (ACD), Calculation of the Total Iron Deficit equation appears in Cosmofer PI, Calculation of the Total Iron Deficit Alternative equation, Iron Dextran Dosing Calculator (iron deficit), HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication, Pharmacosmos A/S, CosmoFer low molecular weight (Mw) iron dextran. Minor/Significance Unknown. David McAuley, Pharm.D. Chandler G, Harchowel J, Macdougall I. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. The dosage of Venofer is expressed in mg of elemental iron. Venofer is manufactured under license from Vifor (International) Inc., Switzerland. Oral and parenteral products - see background option for oral products. restrictions. Your list will be saved and can be edited at any time. Parenteral iron dextran therapy. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Venofer (iron sucrose) dose calculator | Calculosaurus.com Clinical calculators for obstetrics and gynaecology VTE risk assessment Calculator menu Venofer dose calculator Iron sucrose Not what you were looking for? For repletion treatment most patients may require a cumulative dose of 1000 mg of elemental iron administered over 8 dialysis sessions. Iron Product. Applies only to oral form of both agents. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). The prevention and treatment of iron deficiency is a major public health goal, especially in women, children, and individuals in low-income countries. deferasirox decreases levels of iron sucrose by inhibition of GI absorption. 2000 Jan;22(1):39-43. Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Finally, a 400-mg dose by 2-hour infusion was examined in 35 patients, but 2 patients experienced such symptoms as hypotension, nausea, and lower back pain. *Repeat dose if iron deficiency anemia reoccurs. Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Serious - Use Alternative (1)iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Either increases effects of the other by pharmacodynamic synergism. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. If you log out, you will be required to enter your username and password the next time you visit. sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. In this study and another study evaluating a single intravenous dose of iron sucrose containing 500-700 mg of iron in 26 anemic patients on erythropoietin therapy (23 female, 3 male; age range 16-60), approximately 5% of the iron was . Applies only to oral form of both agents. Applies only to oral form of both agents. Use Caution/Monitor. *Administer early during the dialysis session. Nutr Clin Pract. Dose. When to Use Weight lbs Target hemoglobin g/dL Actual hemoglobin g/dL Iron stores Use 500 mg for adults and children 35 kg; use 15 mg/kg if <35 kg mg Result: Please fill out required fields. Applies only to oral form of both agents. Dr. Ganzonis primary research is focused on iron deficiency and plasma iron transport. Feraheme does not contain antimicrobial preservatives. Venofer (Iron Sucrose Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Transferrin saturation (TSAT) values increase rapidly after intravenous administration of iron sucrose; do not perform serum iron measurements for at least 48 hours after intravenous dosing. 3. vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. There is no resource limitation, as if the tool was hosted on your site, so all your users can make use of it 24/7; The necessary tool updates will take place in real time with no effort on your end; A single click install to embed it into your pages, whenever you need to use it. with NDD-CKD or PDD-CKD who are on erythropoietin therapy for iron maintenance treatment, Hemodialysis-dependent chronic kidney disease (HDD-CKD)*, Non-dialysis-dependent chronic kidney disease (NDD-CKD), Peritoneal-dialysis-dependent chronic kidney disease (PDD-CKD), At a dose of 0.5 mg/kg, not to exceed 100 mg per dose, Given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at concentrations of 1 to 2 mg/mL and administered over 5 to 60 minutes, An increase in Hb concentration or a decrease in ESA dose is desired and. Kidney Int. Serum iron, total iron binding capacity (TIBC) and percent saturation of transferrin are other important tests for detecting and monitoring the iron deficient state. This site complies with the HONcode standard for trust- worthy health information: verify here. HOW TO USE: This medication is given by injection into a vein as directed by your doctor. By using this form you agree with the storage and handling of your data by this website. Use Caution/Monitor. 10th ed. MISSED DOSE: It is important to get each dose of this medication as scheduled. Applies only to oral form of both agents. Separate dosing of tetracyclines from these products. Interaction only with oral iron administration. This information is not individual medical advice and does not substitute for the advice of your health care professional. Patients with a history of drug allergy or multiple drug allergies may be at increased risk of anaphylactic-type reactions to INFeD. Avoid or Use Alternate Drug. Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. This drug is available at a middle level co-pay. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Alternatively the total dose may be calculated: Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW) Based on: Desired Hb = the target Hb in g/dl. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Iron deficiency can occur at any stage of life, due to physiological demands, for example, during pregnancy, childhood growth or prolonged periods of sickness. Your doctor will do laboratory tests to monitor your response. Applies only to oral form of both agents. iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Philadelphia, PA: Lippincott Williams & Wilkins;2013;303-307. iron sucrose increases levels of calcium citrate by enhancing GI absorption. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. HONcode standard for trust- worthy health, Pediatric Oncology: Diagnosis And Prognosis Communication. Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Venofer treatment may be repeated if iron deficiency reoccurs. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Avoid or Use Alternate Drug. famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. ------------------------------------------------------------------------- Iron Dextran Complex [ Infed ] Elemental iron: 50 mg of elemental iron per mL [2 mL] [package insert] BOXED WARNING: WARNING: RISK FOR ANAPHYLACTIC-TYPE REACTIONS Anaphylactic-type reactions, including fatalities, have followed the parenteral administration of iron dextran injection. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. commonly, these are "non-preferred" brand drugs or specialty The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Information last revised December 2022. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. Pediatric Patients: The most common adverse reactions (2%) are headache, respiratory tract viral infection, peritonitis, vomiting, pyrexia, dizziness, cough, nausea, arteriovenous fistula thrombosis, hypotension and hypertension. Recommended Treatment Regimen Using IV Iron Sucrose for Initial Repletion in Children With Iron Deficiency Anemia. The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Administer on 5 different occasions over a 14 day period. Ferric gluconate: 12.5 mg/mL Schrier SL, Mentzer WC, Landaw SA. Minor/Significance Unknown. Monitor Closely (1)iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Excessive therapy with parenteral iron can lead to excess storage of iron with the possibility of iatrogenic hemosiderosis. and formulary information changes. Contraindicated. WARNING: RISK FOR SERIOUS HYPERSENSITIVITY/ANAPHYLAXIS REACTIONS Fatal and serious hypersensitivity reactions including anaphylaxis have occurred in patients receiving Feraheme. Oral and parenteral products - see background option for oral products. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). 0.5 mg/kg/min (0.005 mL/kg/min) Maximum infusion rate (if tolerated) Increase to 8 mg/kg/min (0.08 mL/kg/min) Monitor the patient's vital signs throughout the infusion. Where C= concentration of Minor/Significance Unknown. Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD): Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Anemias. INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Monitor Closely (1)esomeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor. Minor/Significance Unknown.iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Use Caution/Monitor. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. DOSAGE AND ADMINISTRATION: The recommended dose of Feraheme is an initial 510 mg dose followed by a second 510 mg dose 3 to 8 days later. 1990 Feb;24(2):162-6. In a randomized, open-label, dose-ranging trial for iron maintenance treatment with Venofer in pediatric patients with CKD on stable erythropoietin therapy [see Clinical Studies ( 14.7)], at least one adverse reaction was experienced by 57% (27/47) of the patients receiving Venofer 0.5 mg/kg, 53% (25/47) of the patients receiving Venofer 1 mg . Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. Minor/Significance Unknown.iron sucrose increases levels of calcium gluconate by enhancing GI absorption. The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. If we don't have the calculator you need then tell us the details and we'll make it for you. Untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia. Your body may also need more iron if you use the drug erythropoietin to help make new red blood cells.Iron is an important part of your red blood cells and is needed to transport oxygen in the body. Maximum infusion rate: 100 mg / hour (Slow infusion rate of iron sucrose is recommended to minimize adverse reactions, especially hypotension) Frequency of infusion: Dose may be repeated up to 3 times weekly to provide total iron dose. 2 *Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. Read our. The dosing for iron replacement treatment in pediatric patients with Peritoneal or Hemodialysis-Dependent - CKD or Non-Dialysis Dependent CKD have not been established. Ferritin and transferrin are also recommended monitoring . Discuss the risks and benefits with your doctor.This medication passes into breast milk. By entering this website, you acknowledge that you are a licensed healthcare professional practicing in the United States. A: Generally acceptable. Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). This website also contains material copyrighted by 3rd parties. 2.1 . Separate dosing of tetracyclines from these products. Hemoglobin can be input in g/dL, g/L or mmol/L and refers to the amount of hemoglobin in the red blood cells. UpToDate. Minor/Significance Unknown. Applies only to oral form of both agents. Avoid or Use Alternate Drug. 1970; 100(7):301-3. All you have to do is use the following formula: Liquid\ dose = Dose / Medicine\ concentration Liquid dose = Dose/M edicine concentration. sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. 3) Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. (1988) Clinical use of the total dose intravenous infusion of iron dextran. 2010;18(3). Where C is the concentration of the iron product: Please note that the calculations above are for information purposes only and the individual dose needs to be established by taking into account the current package insert for the elemental iron product used. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Deferoxamine chelates iron. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. Applies only to oral form of both agents. INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute. The dosage of Venofer is expressed in mg of elemental iron. Volume of iron product required = 25 mL. Congenital Pulmonary Airway Malformation Volume Ratio (CVR) Calculator -. Indicated for treatment of iron deficiency anemia associated with chronic kidney disease, Hemodialysis-dependent CKD: 100 mg elemental iron IV (injection or infusion over 2-5 min) per dialysis session not to exceed total cumulative dose of 1000 mg divided in 3 doses/week, Non-dialysis-dependent CKD: 200 mg IV injection for 5 doses in over 14 days (cumulative 1000 mg in 14-day period), Peritoneal dialysis-dependent CKD: 300 mg IV infusion (1.5 hr) for 2 doses 14 days apart, THEN 400 mg IV infusion (2.5 hr) 14 days later (cumulative 1000 mg divided in 3 doses/week), Indicated for maintenance treatment of iron-deficient anemia associated with chronic kidney disease, <2 years: Safety and efficacy not established, Iron replacement treatment in pediatric patients has not been established. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to Challenges in the treatment of iron deficiency include finding and addressing the underlying cause and the selection of an iron replacement product that meets the needs of the patient. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Venofer must only be administered intravenously either by slow injection or by infusion. Creating an account is free and takes less than 1 minute. Applies only to oral form of both agents. Monitor Closely (1)iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Indications: Feraheme is indicated for the treatment of iron deficiency anemia (IDA) in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron or who have chronic kidney disease (CKD). Written by ASHP. 2012;2(4):288-335. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. No additional iron to replenish stores. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. Minor/Significance Unknown. Separate by 2 hr. Hemoglobin there are two fields for hemoglobin input, one for the target and another for actual value. Hemodialysis-dependent: 0.5 mg/kg IV q2weeks for 12 weeks; not to exceed 100 mg/dose, Non-dialysis dependent or peritoneal-dependent (on erythropoietin): 0.5 mg/kg IV q4weeks for 12 weeks; not to exceed 100 mg/dose, sodium sulfate/?magnesium sulfate/potassium chloride, sodium sulfate/potassium sulfate/magnesium sulfate, Serious hypersensitivity reactions reported, including anaphylactic-type reactions, some of which have been life-threatening and fatal, Patients may present with shock, clinically significant hypotension, loss of consciousness, and/or collapse, If hypersensitivity reactions or signs of intolerance occur during administration, stop infusion immediately, Monitor patients for signs and symptoms of hypersensitivity during and after administration for at least 30 minutes and until clinically stable following completion of the infusion, Animal reproduction studies of iron sucrose administered to rats and rabbits during period of organogenesis at elemental iron doses equivalent to maximum recommended human dose based on body surface area revealed no evidence of harm to the fetus; adverse outcomes in pregnancy occur regardless of health of mother or use of medications, Iron deficiency anemia during pregnancy should be treated; untreated IDA in pregnancy is associated with adverse maternal outcomes such as post-partum anemia; adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight, HD-dependent and non-dialysis-dependent CKD: Dilute with up to 100 mL of 0.9% NaCl, PD-dependent CKD: Dilute with up to 250 mL of 0.9% NaCl, Undiluted: Administer by slow IV injection over 2-5 min, Diluted solutions: Administer IV over 15 min, Undiluted: Administer by slow IV injection over 5 minutes, Diluted solutions: Administer IV over 5-60 minutes, Store in original carton at 20-25C (68-77 F); excursions permitted to 15- 30C (59-86F), Syringe: Store at room temperature (25C) or under refrigeration (4C) for up to 7 days, IV infusion: Store at room temperature (25C) for up to 7 days. May increase risk of hypotension. Kumpf VJ. 300-500 mg Iron Sucrose in NS 250 mL administered over three (3) hours; may repeat as needed in 3-7 days to reach 1 gm. Monitor Closely (1)sodium citrate/citric acid will decrease the level or effect of iron sucrose by increasing gastric pH. Then you can click on the Print button to open a PDF in a separate window with the inputs and results. Use Caution/Monitor. Divide the calculated dose by the patient's weight (IBW if BMI >30, or actual body weight (ABW) if BMI30) to ensure it does NOT exceed 20mg/kg. rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Treatment of anemia due to iron deficiency. Jacobs P, Dommisse J. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. Schweiz Med Wochenschr. Applies only to oral form of both agents. Applies only to oral form of both agents. Although anaphylactic reactions known to occur following INFeD administration are usually evident within a few minutes, or sooner, it is recommended that a period of an hour or longer elapse before the remainder of the initial therapeutic dose is given. Modify Therapy/Monitor Closely. iron sucrose, captopril. Applies only to oral form of both agents. The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Use Caution/Monitor. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Calcs that help predict probability of a disease, Subcategory of 'Diagnosis' designed to be very sensitive, Disease is diagnosed: prognosticate to guide treatment. Use Caution/Monitor. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Generic name: IRON SUCROSE 20mg in 1mL Avoid or Use Alternate Drug. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. Either increases effects of the other by pharmacodynamic synergism. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown. Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling [16.2].) Methods. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL.